ANALGESIC ACTIVITY TEST OF THE ETHANOL EXTRACT OF JAMBU SEED (Psidium guajava L.) ON WHITE MIRES WISTAR DRAIN INDUCED BY ACETIC ACID

Abstract

Pain is unpleasant sensory and emotional experience that result from actual or potential damage. Pan can be caused due to an injury, accident or medical treatment such as surgery. The leaves contain several major compounds such as flavonoid, saponin, tannin, steroid and triterpenoid. The purpose of this study was to determine the extract ethanol analgesic activity of guava leaves (Psidium guajava L) in male white rat wistar strain induced by acetic acid.             This type of research  is purely experimental using a complete random design a uniderctional pattern. This research used 25 male  wistar strain rat, weighing 150-200 gram. Rat were devided into five groups randomly. The first groups group that was given the drug sodium diklofenac 50 mg, the second group as negative group CMC-Na 0,5%, third, fourth and fifth  grups were give ethanol  extract og guava leaves at a dose of 250 mg/kgBB, 300 mg/kgBB, 350 mg/kgBB. After the stretching persent obtained were analysed using the saphiro wilk test, the varience homogeneity test, the proceed with the HSD Tukey test.             Research results show that the dose of ethanol extract of guava 350 mg/kgBB show the most optimal protection and effectiveness approaching the positive control group with stretching protection of 54,152% and stretching  effectivesness of 96,77%.   Keywords: Guava leaves, Flavonoid, Saponin, Tannin, Steroid, Triterpenoid,    Analgesic