AKTIVITAS ANTIARTRITIS KOMBINASI EKSTRAK ETANOL AKAR ALANG-ALANG (Imperata Cilindrica L.) DAN RIMPANG JAHE MERAH (Zingiber Officinale Rosch.) TERHADAP TIKUS YANG DIINDUKSI COMPLETE FREUND’S ADJUVANT (CFA)

Abstract

Arthritis is a desease effecting the musculoskeletal system, muscles, connective tissue, and soft tissue around the joints and bones. Rheumatoid arthritis is a type of arthritis that is caused by an autoimunne reaction. The purpose of this study was determination of Imperata rhizome and red ginger rhizome.             This study used five groups of rats and Complete Frund’s Adjuvant induced 0,2 ml. Each group was given treatment. Group 1 was given a Imperata rhizome rhizome extract single 50 mg/200g BB rats, group 2 was given a red ginger rhizome single 56 mg/200kg BB rats, given a combination of Imperata rhizome rhizome extract and red ginger rhizome, group 4 was given of triaamcinolone, 0,072 mg/200g BB rats, and feed all 5 groups CMC 1%. Test material is administered orally, and edema volume measurements using plethysmograph and seen an increase in body weigth of rats, decrease leucocyte count, percentage decrease of edema volume, and improvement in joint histolopathology profiles foot male rats.             The results showed that the extract of imperata rhizome of imperata rhizome has the ability to reduce both the volume of the edema, and red ginger has thre ability to lose weight. While the repair joint histopathology profiles produced by the positive control triamcinolone. Combination of red ginger rhizome extract and imperata red ginger have the ability to reduce the number of leucocyte. Keywords : imperata rhizome, red ginger rhizome, complete freund’s adjuvant, antiarthritis, triamcinolone.